Hypothalamus Archives - Inscopix, Inc.

Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity

Jaime E. Heiss et al.
PNAS | April 9, 2024
For nearly a century, evidence has accumulated indicating that the lateral hypothalamus (LH) contains neurons essential to sustain wakefulness. While lesion or inactivation of LH neurons produces a profound increase in...

Most dynorphin neurons in the zona incerta-perifornical area are active in waking relative to non-rapid-eye movement and rapid-eye movement sleep

Priyattam J Shiromani et al.
Sleep | March 6, 2024
Dynorphin is an endogenous opiate localized in many brain regions and spinal cord, but the activity of dynorphin neurons during sleep is unknown. Dynorphin is an inhibitory neuropeptide that is coreleased with orexin,...

Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state

In-Jee You et al.
Nature Communications | October 28, 2023
Psychological stressors, like the nearby presence of a predator, can be strong enough to induce physiological/hormonal alterations, leading to appetite changes. However, little is known about how threats can alter...

Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy

RACHIDA AMMARI et al.
Science | October 5, 2023
During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but...

Immediate responses to ambient light in vivo reveal distinct subpopulations of suprachiasmatic VIP neurons

Anat Kahan et al.
iScience | September 8, 2023
The circadian rhythm pacemaker, the suprachiasmatic nucleus (SCN), mediates light entrainment via vasoactive intestinal peptide (VIP) neurons (SCNVIP). Yet, how these neurons uniquely respond and connect to...

Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain

Yaling Liu et al.
Neuron | April 4, 2023
Liu et al. conducted a study on rats to investigate the neural mechanisms involved in pain processing and modulation. Using behavioral assays and calcium imaging techniques, they sought to understand how oxytocin...

Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

Young Hee Lee et al.
Nature Communications | March 17, 2023
For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known to regulate motivated behaviours, yet...

Hypothalamic neurons that mirror aggression

Taehong Yang et al.
Cell | February 15, 2023
Social interactions require awareness and understanding of the behavior of others. Mirror neurons, cells representing an action by self and others, have been proposed to be integral to the cognitive substrates that...

Arginine–vasopressin-expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo

Adam Stowie et al.
PNAS | January 19, 2023
The suprachiasmatic nucleus (SCN) is composed of functionally distinct subpopulations of GABAergic neurons which form a neural network responsible for synchronizing most physiological and behavioral circadian rhythms in...

An approximate line attractor in the hypothalamus encodes an aggressive state

Aditya Nair et al.
Cell | January 11, 2023
The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA and VMHvl, respectively....

Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area

Sasa Teng et al.
Nature Communications | August 12, 2022
Understanding the neural mechanisms underlying sleep state transitions is a fundamental goal of neurobiology and important for the development of new treatments for insomnia and other sleep disorders. Yet, brain...

Dopamine subsystems that track internal states

James C. R. Grove et al.
Nature | July 13, 2022
Food and water are rewarding in part because they satisfy our internal needs. Dopaminergic neurons in the ventral tegmental area (VTA) are activated by gustatory rewards, but how animals learn to associate these oral...

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Publication Category: Hypothalamus