Fear and anxiety Archives - Page 3 of 4

Amygdala ensembles encode behavioral states

Jan Gründemann et al.
Science | April 19, 2019
Internal states, including affective or homeostatic states, are important behavioral motivators. The amygdala regulates motivated behaviors, yet how distinct states are represented in amygdala circuits is unknown. By...

In vivo calcium imaging reveals that cortisol treatment reduces the number of place cells in Thy1-GCaMP6f transgenic mice.

Tim Indersmitten et al.
Frontiers in Neuroscience | March 1, 2019
The hippocampus, a structure essential for spatial navigation and memory undergoes anatomical and functional changes during chronic stress. Here, we investigate the effects of chronic stress on the ability of place...

Divergent medial amygdala projections regulate approach–avoidance conflict behavior

Samara M. Miller et al.
Nature Neuroscience | February 25, 2019
Avoidance of innate threats is often in conflict with motivations to engage in exploratory approach behavior. The neural pathways that mediate this approach–avoidance conflict are not well resolved. Here we isolated a...

A hypothalamus-habenula circuit controls aversion

Iakovos Lazaridis et al.
Molecular Psychiatry | February 12, 2019
Encoding and predicting aversive events are critical functions of circuits that support survival and emotional well-being. Maladaptive circuit changes in emotional valence processing can underlie the pathophysiology of...

Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses

Antoine Besnard et al.
Nature Neuroscience | February 4, 2019
Adaptive fear responses to external threats rely upon efficient relay of computations underlying contextual encoding to subcortical circuits. Brain-wide analysis of highly coactivated ensembles following contextual fear...

Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode

Changwoo Seo et al.
Science | January 31, 2019
Survival depends on the selection of behaviors adaptive for the current environment. For example, a mouse should run from a rapidly looming hawk but should freeze if the hawk is coasting across the sky. Although...

An amygdalar neural ensemble that encodes the unpleasantness of pain

Gregory Corder et al.
Science | January 17, 2019
Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural...

Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect

et al.
Molecular Psychiatry | November 30, 2018
Benzodiazepines (BZDs) have been a standard treatment for anxiety disorders for decades, but the neuronal circuit interactions mediating their anxiolytic effect remain largely unknown. Here, we find that systemic BZDs...

Dorsal tegmental dopamine neurons gate associative learning of fear

Florian Groessl et al.
Nature Neuroscience | June 27, 2018
Functional neuroanatomy of Pavlovian fear has identified neuronal circuits and synapses associating conditioned stimuli with aversive events. Hebbian plasticity within these networks requires additional reinforcement to...

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus

Christoph Anacker et al.
Nature | June 27, 2018
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1,2,3,4. However, how...

Stress peptides sensitize fear circuitry to promote passive coping

Pinelopi Pliota et al.
Molecular Psychiatry | June 18, 2018
Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances...

Encoding of Danger by Parabrachial CGRP Neurons

Carlos A. Campos et al.
Nature | March 21, 2018
Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN neurons) relay sensory signals that contribute to satiation and pain-induced...

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Publication Category: Fear and anxiety