Learning and Memory Archives - Page 3 of 7

A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations

Lingjie He et al.
Neuron | May 18, 2022
Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can...

Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning

Nathan F. Parker et al.
Cell Reports | May 17, 2022
How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens, which is implicated in this process, receives glutamatergic inputs from the prelimbic cortex and midline regions of the thalamus....

The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels

Kyosuke Hirano et al.
Scientific Reports | May 12, 2022
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance its release in most brain regions, including the...

Encoding of environmental cues in central amygdala neurons during foraging

Marion Ponserre et al.
The Journal of Neuroscience | April 5, 2022
To successfully forage in an environment filled with rewards and threats, animals need to rely on familiar structures of their environment that signal food availability. The central amygdala (CeA) is known to mediate a...

A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation

Hannah Twarkowski et al.
eLife | February 22, 2022
Memories encoded in the dentate gyrus (DG) ‒ CA3 circuit of the hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although CA1 parvalbumin inhibitory neurons (PV INs) orchestrate...

Stepwise synaptic plasticity events drive the early phase of memory consolidation

Akihiro Goto et al.
Science | November 11, 2021
Memories are initially encoded in the hippocampus but subsequently consolidated to the cortex. Although synaptic plasticity is key to these processes, its precise spatiotemporal profile remains poorly understood. Using...

Neural dynamics underlying birdsong practice and performance

Jonnathan Singh Alvarado et al.
Nature | October 20, 2021
Musical and athletic skills are learned and maintained through intensive practice to enable precise and reliable performance for an audience. Consequently, understanding such complex behaviours requires insight into how...

Dentate Granule Cells Encode Reinforcement Learning

Jia Shen et al.
Scientific Reports | July 13, 2021
DGCs’ activity predicts auditory decisions after task learning

Single cell plasticity and population coding stability in auditory thalamus upon associative learning

James Alexander Taylor et al.
Nature Communications | April 26, 2021
Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains...

Lateral VTA modulates conditioned learning

Giorgio Rizzi et al.
Cell Reports | March 16, 2021
lVTA Vgat and Vglut2 projections onto dmCINs influence aversive stimuli encoding

Lateral ventral tegmental area GABAergic and glutamatergic modulation of conditioned learning

Giorgio Rizzi et al.
Cell Reports | March 16, 2021
The firing activity of dorso-medial-striatal-cholinergic interneurons (dmCINs) is a neural correlate of classical conditioning. Tonically active, they pause in response to salient stimuli, mediating acquisition of...

Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice

Pablo Vergara et al.
International Journal of Molecular Sciences | March 12, 2021
The mammalian hippocampal dentate gyrus is a unique memory circuit in which a subset of neurons is continuously generated throughout the lifespan. Previous studies have shown that the dentate gyrus neuronal population...

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