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Calcium imaging of sleep–wake related neuronal activity in the dorsal pons


Authors: Julia Cox, Lucas Pinto, Yang Dan
Publication: Nature Communications
Date: February 25, 2016
Link to article: https://media.inscopix.com/cs/c/?cta_guid=09698806-23de-40dc-b7d9-f77382de2400&…


The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max).

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