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Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses


Authors: Shanna L Resendez, Josh H Jennings, Randall L Ung, Vijay Mohan K Namboodiri, Zhe Charles Zhou, James M Otis, Hiroshi Nomura, Jenna A McHenry, Oksana Kosyk, Garret D Stuber
Publication: Nature Protocols
Date: February 25, 2016
Link to article: https://media.inscopix.com/cs/c/?cta_guid=a60a52dd-2d6d-4ff2-bb83-d20a404846ed&…


Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly expanded our understanding of the brain. However, owing to the light-scattering properties of the brain, as well as the size and rigidity of traditional imaging technology, in vivo calcium imaging has been limited to superficial brain structures during head-fixed behavioral tasks.

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