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Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice


Authors: Tamara K. Berdyyeva, E. Paxon Frady, Jonathan J. Nassi, Leah Aluisio, Yauheniya Cherkas, Stephani Otte, Ryan M. Wyatt, Christine Dugovic, Kunal K. Ghosh, Mark J. Schnitzer, Timothy Lovenberg, Pascal Bonaventure
Publication: Frontiers in Neuroscience
Date: February 29, 2016
Link to article: https://www.frontiersin.org/articles/10.3389/fnins.2016.00053/full


Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior study has characterized calcium activity during seizures in the live, intact hippocampus. We have directly investigated this possibility by combining whole-brain electroencephalographic (EEG) measurements with microendoscopic calcium imaging of pyramidal cells in the CA1 hippocampal region of freely behaving mice treated with the pro-convulsant kainic acid (KA).

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