Cortex Archives - Page 3 of 5

Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque

Anil Bollimunta et al.
Cell Reports | June 15, 2021
Microendoscopic calcium imaging with one-photon miniature microscopes enables unprecedented readout of neural circuit dynamics during active behavior in rodents. In this study, we describe successful application of this...

Independent and distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine

Elizabeth E. Manning et al.
Biological Psychiatry | March 3, 2021
Background Patients with obsessive-compulsive disorder (OCD) display disrupted performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal learning tasks, yet it is unknown whether compulsions...

The amygdala instructs insular feedback for affective learning

Dominic Kargl et al.
eLife | November 20, 2020
Affective responses depend on assigning value to environmental predictors of threat or reward. Neuroanatomically, this affective value is encoded at both cortical and subcortical levels. However, the purpose of this...

The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection

Thomas Akam et al.
Neuron | November 4, 2020
Behavioral control is not unitary. It comprises parallel systems, model based and model free, that respectively generate flexible and habitual behaviors. Model-based decisions use predictions of the specific...

A Role for Astroglial Calcium in Mammalian Sleep and Sleep Regulation

Ashley M. Ingiosi et al.
Current Biology | September 24, 2020
Mammalian sleep expression and regulation have historically been thought to reflect the activity of neurons. Changes in other brain cells (glia) across the sleep-wake cycle and their role in sleep regulation are...

Encoding of social exploration by neural ensembles in the insular cortex

et al.
PLOS Biology | September 21, 2020
The insular cortex (IC) participates in diverse complex brain functions, including social function, yet their cellular bases remain to be fully understood. Using microendoscopic calcium imaging of the agranular insular...

Action representation in the mouse parieto-frontal network

Tuce Tombaz et al.
Scientific Reports | March 27, 2020
The posterior parietal cortex (PPC) and frontal motor areas comprise a cortical network supporting goal-directed behaviour, with functions including sensorimotor transformations and decision making. In primates, this...

Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex

Taekeun Kim et al.
Frontiers in Cellular Neuroscience | January 14, 2020
Daily exposure of awake mice to a phase-reversing visual grating stimulus leads to enhancement of the visual-evoked potential (VEP) in layer 4 of the primary visual cortex (V1). This stimulus-selective response...

Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

Diego Scheggia et al.
Nature Neuroscience | December 16, 2019
The prefrontal cortex (PFC) is implicated in processing of the affective state of others through non-verbal communication. This social cognitive function is thought to rely on an intact cortical neuronal excitatory and...

Cortical ensemble activity discriminates auditory attentional states

Pan-tong Yao et al.
Molecular Brain | October 17, 2019
Selective attention modulates sensory cortical activity. It remains unclear how auditory cortical activity represents stimuli that differ behaviorally. We designed a cross-modality task in which mice made decisions to...

Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior

Vamsi K Daliparthi et al.
eLife | June 11, 2019
Precise neural sequences are associated with the production of well-learned skilled behaviors. Yet, how neural sequences arise in the brain remains unclear. In songbirds, premotor projection neurons in the cortical song...

Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons

Courtney M. Cameron et al.
Neuron | May 14, 2019
Craving for cocaine progressively increases in cocaine users during drug-free periods, contributing to relapse. The projection from the infralimbic cortex to the nucleus accumbens shell (IL-NAc) is thought to inhibit...

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