Hippocampus Archives - Page 3 of 6

Olfactory landmarks and path integration converge to form a cognitive spatial map

Walter Fischler-Ruiz et al.
Neuron | October 27, 2021
The convergence of internal path integration and external sensory landmarks generates a cognitive spatial map in the hippocampus. We studied how localized odor cues are recognized as landmarks by recording the activity...

Dentate Granule Cells Encode Reinforcement Learning

Jia Shen et al.
Scientific Reports | July 13, 2021
DGCs’ activity predicts auditory decisions after task learning

Dentate granule cells encode auditory decisions after reinforcement learning in rats

Jia Shen et al.
Scientific Reports | July 13, 2021
Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with goal locations through learning remains poorly...

A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing

Dong-oh Seo et al.
Neuron | June 2, 2021
Dysregulation in contextual processing is believed to affect several forms of psychopathology, such as post-traumatic stress disorder (PTSD). The dentate gyrus (DG), a subregion of the hippocampus, is thought to be an...

Calcium imaging of adult-born neurons in freely moving mice

Alvaro Carrier-Ruiz et al.
STAR Protocols | March 19, 2021
Adult-born neurons (ABNs) in the dentate gyrus bestow unique cellular plasticity to the mammalian brain. We recently found that the activity of ABNs during sleep is necessary for memory consolidation. Here, we describe...

Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice

Pablo Vergara et al.
International Journal of Molecular Sciences | March 12, 2021
The mammalian hippocampal dentate gyrus is a unique memory circuit in which a subset of neurons is continuously generated throughout the lifespan. Previous studies have shown that the dentate gyrus neuronal population...

Concussion increases CA1 activity during prolonged inactivity in a familiar environment

Shanti R. Tummala et al.
Experimental Neurology | August 17, 2020
Although hippocampal damage plays a key role in impairments after concussion, differences in hippocampal information processing during recovery are unknown. Micro-endoscopic calcium imaging was performed before and...

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

Jessica C. Jimenez et al.
Nature Communications | July 13, 2020
Ventral hippocampal CA1 (vCA1) projections to the amygdala are necessary for contextual fear memory. Here we used in vivo Ca2+ imaging in mice to assess the temporal dynamics by which ensembles of vCA1 neurons mediate...

A Distributed Neural Code in the Dentate Gyrus and in CA1

Fabio Stefanini et al.
Neuron | June 9, 2020
Neurons are often considered specialized functional units that encode a single variable. However, many neurons are observed to respond to a mix of disparate sensory, cognitive, and behavioral variables. For such...

Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Deependra Kumar et al.
Neuron | June 4, 2020
The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory. Within the mammalian hippocampus, the dentate gyrus (DG) has the...

Trajectory-modulated hippocampal neurons persist throughout memory-guided navigation

Nathaniel R. Kinsky et al.
Nature Communications | May 15, 2020
Trajectory-dependent splitter neurons in the hippocampus encode information about a rodent’s prior trajectory during performance of a continuous alternation task. As such, they provide valuable information for...

Multiple Maps of the Same Spatial Context Can Stably Coexist in the Mouse Hippocampus

Liron Sheintuch et al.
Current Biology | April 20, 2020
Hippocampal place cells selectively fire when an an- imal traverses a particular location and are consid- ered a neural substrate of spatial memory. Place cells were shown to change their activity patterns (remap)...

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Publication Category: Hippocampus