nVista Archives - Inscopix

Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model

Shiri Shoob et al.
Nature Communications | November 2, 2023
The mechanisms that confer cognitive resilience to Alzheimer’s Disease (AD) are not fully understood. Here, we describe a neural circuit mechanism underlying this resilience in a familial AD mouse model. In the...

Binge Feeding Promotes Appetite via Modulating Olfactory Flavor Representation

Hung Lo et al.
bioRxiv | October 17, 2023
Binge eating commonly leads to overeating, but the exact mechanism is unclear. While it is known that experiencing flavor contributes to satiety, the interactions between flavor, feeding rate, and food intake remain...

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Hansol Lim et al.
bioRxiv | October 17, 2023
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of...

Neuronal Ensembles in the Infralimbic Cortex Dynamically Process Distinct Aspects of Hedonic Value

Seth W. Hurley et al.
Journal of Neuroscience | October 10, 2023
Hedonic processing is critical for guiding appropriate behavior, and the infralimbic cortex (IL) is a key neural substrate associated with this function in rodents and humans. We used deep brain, in vivo calcium imaging...

Immediate responses to ambient light in vivo reveal distinct subpopulations of suprachiasmatic VIP neurons

Anat Kahan et al.
iScience | September 8, 2023
The circadian rhythm pacemaker, the suprachiasmatic nucleus (SCN), mediates light entrainment via vasoactive intestinal peptide (VIP) neurons (SCNVIP). Yet, how these neurons uniquely respond and connect to...

Unilateral Optogenetic Stimulation of Lhx6 Neurons in the Zona Incerta Increases REM sleep

Aurelio Vidal-Ortiz et al.
Sleep | August 21, 2023
To determine how a waking brain falls asleep researchers have monitored and manipulated activity of neurons and glia in various brain regions. While imaging GABA neurons in the zona incerta (ZI) we found a subgroup that...

A neural circuit for male sexual behavior and reward

Daniel W. Bayless et al.
Cell | August 11, 2023
A study conducted by Bayless et al. explores the neural basis of innate male sexual behavior and its rewarding nature. Using nVista for calcium imaging and fiber photometry, the researchers identified a developmentally...

A neural mechanism for discriminating social threat from social safety

Pegah Kassraian et al.
bioRxiv | July 27, 2023
The ability to distinguish a threatening from non-threatening conspecific based on past experience is critical for adaptive social behaviors. Although recent progress has been made in identifying the neural circuits...

Self-organization of songbird neural sequences during social isolation

Emily L Mackevicius et al.
eLife | May 30, 2023
Emily L. Mackevicius et al., using the Inscopix nVista tool, investigated whether the formation of sequences in the high vocal center (HVC) of songbirds depends on prior exposure to a tutor song. They found that even in...

Long-term optical imaging of the spinal cord in awake, behaving animals

Biafra Ahanonu et al.
bioRxiv | May 24, 2023
Advances in optical imaging approaches and fluorescent biosensors have enabled an understanding of the spatiotemporal and long-term neural dynamics in the brain of awake animals. However, methodological difficulties and...

Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia

Satvinder Kaur et al.
Research Square | May 5, 2023
Although CGRP neurons in the external lateral parabrachial nucleus (PBelCGRP neurons) are critical for cortical arousal in response to hypercapnia, activating them has little effect on respiration. However, deletion of...

Identification of an essential spinoparabrachial pathway for mechanical itch

Xiangyu Ren et al.
Neuron | April 5, 2023
The study identified a specific population of neurons that transmit mechanical itch from the spinal cord to the parabrachial nucleus (PBN) in the brain, and separate populations of neurons in the PBN relay mechanical...

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