nVista Archives - Inscopix, Inc.

Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity

Jaime E. Heiss et al.
PNAS | April 9, 2024
For nearly a century, evidence has accumulated indicating that the lateral hypothalamus (LH) contains neurons essential to sustain wakefulness. While lesion or inactivation of LH neurons produces a profound increase in...

Parabrachial Calca neurons drive nociplasticity

Logan F. Condon et al.
Cell Reports | April 6, 2024
Pain that persists beyond the time required for tissue healing and pain that arises in the absence of tissue injury, collectively referred to as nociplastic pain, are poorly understood phenomena mediated by plasticity...

Selective engagement of prefrontal VIP neurons in reversal learning

Jee Hyun Yi et al.
bioRxiv | April 5, 2024
To gain insights into neural mechanisms enabling behavioral adaptations to complex and multidimensional environmental dynamics, we examined roles of VIP neurons in mouse medial prefrontal cortex (mPFC) in probabilistic...

A role for the cerebellum in motor-triggered alleviation of anxiety

Xiao-Yang Zhang et al.
Neuron | April 3, 2024
Physical exercise is known to reduce anxiety, but the underlying brain mechanisms remain unclear. Here, we explore a hypothalamo-cerebello-amygdalar circuit that may mediate motor-dependent alleviation of anxiety. This...

Parabrachial Calca neurons mediate second-order conditioning

Sekun Park et al.
bioRxiv | March 25, 2024
Learning to associate cues, both directly and indirectly, with biologically significant events is essential for survival. Second-order conditioning (SOC) involves forming an association between a previously reinforced...

A persistent prefrontal reference frame across time and task rules

Hannah Muysers et al.
Nature Communications | March 8, 2024
Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently...

Heterogeneous subpopulations of GABA_AR-responding neurons coexist across neuronal networks scales and developmental stages in health and disease

I. Colombi et al.
iScience | March 8, 2024
GABA is the main inhibitory neurotransmitter in adults. Depolarizing GABA responses have been well characterized at neuronal-population average level during typical neurodevelopment and partially in brain disorders....

Most dynorphin neurons in the zona incerta-perifornical area are active in waking relative to non-rapid-eye movement and rapid-eye movement sleep

Priyattam J Shiromani et al.
Sleep | March 6, 2024
Dynorphin is an endogenous opiate localized in many brain regions and spinal cord, but the activity of dynorphin neurons during sleep is unknown. Dynorphin is an inhibitory neuropeptide that is coreleased with orexin,...

Tuned geometries of hippocampal representations meet the computational demands of social memory

Lara M. Boyle et al.
Neuron | February 20, 2024
Social memory consists of two processes: the detection of familiar compared with novel conspecifics and the detailed recollection of past social episodes. We investigated the neural bases for these processes using...

Dopamine neuron activity encodes the length of upcoming contralateral movement sequences

Marcelo D. Mendonça et al.
Current Biology | February 19, 2024
Dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement speed, and loss of these neurons leads to bradykinesia in Parkinson’s disease (PD). However, other aspects of...

A distinct cortical code for socially learned threat

Shana E. Silverstein et al.
Nature | February 7, 2024
Animals can learn about sources of danger while minimizing their own risk by observing how others respond to threats. However, the distinct neural mechanisms by which threats are learned through social observation...

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Xia Zhu et al.
Nature Neuroscience | January 30, 2024
Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in male mice with acute versus chronic...

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