nVista Archives - Page 17 of 17

Cellular level brain imaging in behaving mammals: an engineering approach

Elizabeth J. O. Hamel et al.
Neuron | April 8, 2015
Fluorescence imaging offers expanding capabilities for recording neural dynamics in behaving mammals, including the means to monitor hundreds of cells targeted by genetic type or connectivity, track cells over weeks,...

Cell-type-specific activity in prefrontal cortex during goal-directed behavior

Lucas Pinto et al.
Neuron | February 7, 2015
The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types...

Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors

Joshua H. Jennings et al.
Cell | January 29, 2015
Optimally orchestrating complex behavioral states, such as the pursuit and consumption of food, is critical for an organism’s survival. The lateral hypothalamus (LH) is a neuroanatomical region essential for...

Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope

Tamara Berdyyeva et al.
PLOS ONE | November 5, 2014
Therapeutic drugs for cognitive and psychiatric disorders are often characterized by their molecular mechanism of action. Here we demonstrate a new approach to elucidate drug action on large-scale neuronal activity by...

Tools for resolving functional activity and connectivity within intact neural circuits

Joshua H. Jennings et al.
Current Biology | January 6, 2014
Mammalian neural circuits are sophisticated biological systems that choreograph behavioral processes vital for survival. While the inherent complexity of discrete neural circuits has proven difficult to decipher, many...

Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex

Jerry L. Chen et al.
The Journal of Neuroscience | November 6, 2013
Understanding the neural correlates of behavior in the mammalian cortex requires measurements of activity in awake, behaving animals. Rodents have emerged as a powerful model for dissecting the cortical circuits...

Engineering approaches to illuminating brain structure and dynamics

Karl Deisseroth et al.
Neuron | October 30, 2013
Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask...

Long-term dynamics of CA1 hippocampal place codes

Yaniv Ziv et al.
Nature Neuroscience | February 10, 2013
Using Ca2+ imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells’ place fields over weeks. Place coding was dynamic, as each day the ensemble...

Miniaturized integration of a fluorescence microscope

Kunal K Ghosh et al.
Nature Methods | September 11, 2011
The light microscope is traditionally an instrument of substantial size and expense. Its miniaturized integration would enable many new applications based on mass-producible, tiny microscopes. Key prospective usages...

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