nVista Archives - Page 2 of 17

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Xia Zhu et al.
Nature Neuroscience | January 30, 2024
Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in male mice with acute versus chronic...

Differential contribution of distinct neuronal populations to danger representations

Ana Paula Menegolla et al.
bioRxiv | January 24, 2024
The recognition of specific stimuli and contexts in dangerous situations determines the expression of behaviors needed to appropriately cope with each threatening encounter. Moreover, the detection of common features...

Dynamic and selective engrams emerge with memory consolidation

Douglas Feitosa Tomé et al.
Nature Neuroscience | January 19, 2024
Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this...

Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days

Ole Christian Sylte et al.
PLOS Biology | January 11, 2024
Intense threat elicits action in the form of active and passive coping. The medial prefrontal cortex (mPFC) executes top-level control over the selection of threat coping strategies, but the dynamics of mPFC activity...

Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

Amol M. Bhandare et al.
Frontiers in Cellular Neuroscience | December 20, 2023
While central autonomic, cardiac, and/or respiratory dysfunction underlies sudden unexpected death in epilepsy (SUDEP), the specific neural mechanisms that lead to SUDEP remain to be determined. In this study, we took...

Functional alterations of the prefrontal circuit underlying cognitive aging in mice

Huee Ru Chong et al.
Nature Communications | November 9, 2023
Executive function is susceptible to aging. How aging impacts the circuit-level computations underlying executive function remains unclear. Using calcium imaging and optogenetic manipulation during memory-guided...

Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model

Shiri Shoob et al.
Nature Communications | November 2, 2023
The mechanisms that confer cognitive resilience to Alzheimer’s Disease (AD) are not fully understood. Here, we describe a neural circuit mechanism underlying this resilience in a familial AD mouse model. In the...

Binge Feeding Promotes Appetite via Modulating Olfactory Flavor Representation

Hung Lo et al.
bioRxiv | October 17, 2023
Binge eating commonly leads to overeating, but the exact mechanism is unclear. While it is known that experiencing flavor contributes to satiety, the interactions between flavor, feeding rate, and food intake remain...

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Hansol Lim et al.
bioRxiv | October 17, 2023
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of...

Neuronal Ensembles in the Infralimbic Cortex Dynamically Process Distinct Aspects of Hedonic Value

Seth W. Hurley et al.
Journal of Neuroscience | October 10, 2023
Hedonic processing is critical for guiding appropriate behavior, and the infralimbic cortex (IL) is a key neural substrate associated with this function in rodents and humans. We used deep brain, in vivo calcium imaging...

Immediate responses to ambient light in vivo reveal distinct subpopulations of suprachiasmatic VIP neurons

Anat Kahan et al.
iScience | September 8, 2023
The circadian rhythm pacemaker, the suprachiasmatic nucleus (SCN), mediates light entrainment via vasoactive intestinal peptide (VIP) neurons (SCNVIP). Yet, how these neurons uniquely respond and connect to...

Unilateral Optogenetic Stimulation of Lhx6 Neurons in the Zona Incerta Increases REM sleep

Aurelio Vidal-Ortiz et al.
Sleep | August 21, 2023
To determine how a waking brain falls asleep researchers have monitored and manipulated activity of neurons and glia in various brain regions. While imaging GABA neurons in the zona incerta (ZI) we found a subgroup that...

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