nVista Archives - Page 16 of 17

Decreasing striatopallidal pathway function enhances motivation by energizing the initiation of goal-directed action

Fernanda Carvalho Poyraz et al.
The Journal of Neuroscience | June 1, 2016
Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in...

Calcium imaging of basal forebrain activity during innate and learned behavio

Thomas C. Harrison et al.
Frontiers in Neural Circuits | May 9, 2016
The basal forebrain (BF) plays crucial roles in arousal, attention, and memory, and its impairment is associated with a variety of cognitive deficits. The BF consists of cholinergic, GABAergic, and glutamatergic...

Neurons for hunger and thirst transmit a negative-valence teaching signal

J. Nicholas Betley et al.
Nature | April 27, 2016
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational...

Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Tamara K. Berdyyeva et al.
Frontiers in Neuroscience | February 29, 2016
Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior study has characterized calcium activity during...

Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

Julia Cox et al.
Nature Communications | February 25, 2016
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and...

Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses

Shanna L Resendez et al.
Nature Protocols | February 25, 2016
Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly expanded our understanding of the brain. However, owing to the light-scattering properties of the brain, as well as the size...

Hippocampal ensemble dynamics timestamp events in long-term memory

Alon Rubin et al.
eLife | December 18, 2015
The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms. We performed time-lapse imaging of thousands of...

Entorhinal cortical ocean cells encode specific contexts and drive context-specific fear memory

Takashi Kitamura et al.
Neuron | September 23, 2015
Forming distinct representations and memories of multiple contexts and episodes is thought to be a crucial function of the hippocampal-entorhinal cortical network. The hippocampal dentate gyrus (DG) and CA3 are known to...

Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction

Benjamin T. Saunders et al.
Biological Sciences | September 19, 2015
Tying complex psychological processes to precisely defined neural circuits is a major goal of systems and behavioural neuroscience. This is critical for understanding adaptive behaviour, and also how neural systems are...

Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells

Chen Sun et al.
PNAS | July 13, 2015
Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex...

Mesoscopic patterns of neural activity support songbird cortical sequences

Jeffrey E. Markowitz et al.
PLOS Biology | June 3, 2015
Time-locked sequences of neural activity can be found throughout the vertebrate forebrain in various species and behavioral contexts. From “time cells” in the hippocampus of rodents to cortical activity controlling...

Hunger logic

et al.
Nature Neuroscience | May 26, 2015
Activation of AgRP-expressing ‘hunger’ neurons promotes robust feeding. Recent studies reveal the valence, dynamics and neural circuits engaged by AgRP neurons.

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