nVoke Archives - Inscopix, Inc.

Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states

Huikun Wang et al.
Neuron | April 12, 2024
Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has...

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons

Ana Verónica Domingues et al.
bioRxiv | February 23, 2024
The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct neuronal populations encode appetitive or aversive stimuli remains undetermined. Using microendoscopic calcium imaging, we...

Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice

Jared M. Cregg et al.
Nature Neuroscience | February 12, 2024
The basal ganglia are essential for executing motor actions. How the basal ganglia engage spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons are required for turning gait programs,...

Memory encoding and retrieval by retrosplenial parvalbumin interneurons are impaired in Alzheimer’s disease model mice

Kyerl Park et al.
Current Biology | January 22, 2024
Memory deficits in Alzheimer’s disease (AD) show a strong link with GABAergic interneuron dysfunctions. The ensemble dynamics of GABAergic interneurons represent memory encoding and retrieval, but how GABAergic...

Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite

Takashi Matsuda et al.
Cell Reports | December 28, 2023
Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay...

Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals

Mary L. Phillips et al.
bioRxiv | December 14, 2023
Head-mounted miniscopes have allowed for functional fluorescence imaging in freely moving animals. However, current capabilities of state-of-the-art technology can record only up to two, spectrally distinct...

Motor cortex somatostatin interneurons adaptively shape the structure of motor sequences

Jeong Oen Lee et al.
bioRxiv | November 29, 2023
The brain can flexibly reorganize motor sequence, or program, execution to efficiently reach positive outcomes. These behavioral adaptations are primarily driven by reinforcement learning, leading to structural and...

Emergence of task-related spatiotemporal population dynamics in transplanted neurons

Harman Ghuman et al.
Nature Communications | November 11, 2023
Loss of nervous system tissue after severe brain injury is a main determinant of poor functional recovery. Cell transplantation is a promising method to restore lost tissue and function, yet it remains unclear if...

Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state

In-Jee You et al.
Nature Communications | October 28, 2023
Psychological stressors, like the nearby presence of a predator, can be strong enough to induce physiological/hormonal alterations, leading to appetite changes. However, little is known about how threats can alter...

Context-invariant socioemotional encoding by prefrontal ensembles

Nicholas A. Frost et al.
bioRxiv | October 23, 2023
The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information...

Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats

Hyun Jung Jee et al.
Molecular Brain | October 13, 2023
Negative pain expectation including pain catastrophizing is a well-known clinical phenomenon whereby patients amplify the aversive value of a painful or oftentimes even a similar, non-painful stimulus. Mechanisms of...

Early life stress impairs VTA coordination of BLA network and behavioral states

Bradly T. Stone et al.
bioRxiv | September 17, 2023
Motivated behaviors, such as social interactions, are governed by the interplay between mesocorticolimbic structures, such as the ventral tegmental area (VTA), basolateral amygdala (BLA), and medial prefrontal cortex...

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