nVoke Archives - Page 4 of 5

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Débora Masini et al.
Nature Communications | January 26, 2022
The pedunculopontine nucleus (PPN) is a locomotor command area containing glutamatergic neurons that control locomotor initiation and maintenance. These motor actions are deficient in Parkinson’s disease (PD), where...

Identification of Sclareol As a Natural Neuroprotective Ca_v1.3-Antagonist Using Synthetic Parkinson-Mimetic Gene Circuits and Computer-Aided Drug Discovery

Hui Wang et al.
Advanced Science | January 18, 2022
Parkinson’s disease (PD) results from selective loss of substantia nigra dopaminergic (SNc DA) neurons, and is primarily caused by excessive activity-related Ca2+ oscillations. Although L-type voltage-gated...

Disrupted population coding in the prefrontal cortex underlies pain aversion

Anna Li et al.
Cell Reports | November 9, 2021
The prefrontal cortex (PFC) regulates a wide range of sensory experiences. Chronic pain is known to impair normal neural response, leading to enhanced aversion. However, it remains unknown how nociceptive responses in...

In vivo Calcium Imaging in Mouse Inferior Olive

Da Guo et al.
JOVE | June 10, 2021
Inferior olive (IO), a nucleus in the ventral medulla, is the only source of climbing fibers that form one of the two input pathways entering the cerebellum. IO has long been proposed to be crucial for motor control and...

Single cell plasticity and population coding stability in auditory thalamus upon associative learning

James Alexander Taylor et al.
Nature Communications | April 26, 2021
Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains...

Lateral VTA modulates conditioned learning

Giorgio Rizzi et al.
Cell Reports | March 16, 2021
lVTA Vgat and Vglut2 projections onto dmCINs influence aversive stimuli encoding

Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

Jan H. Lui et al.
Cell | December 17, 2020
Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience has historically analyzed the encoding properties of cortical neurons without considering cell...

Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake

Takashi Matsuda et al.
Nature Communications | November 10, 2020
The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water...

An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration

Paolo Botta et al.
Cell | October 7, 2020
Exploration of novel environments ensures survival and evolutionary fitness. It is expressed through exploratory bouts and arrests that change dynamically based on experience. Neural circuits mediating exploratory...

Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures

James K Trevathan et al.
Journal of Neural Engineering | September 11, 2020
After decades of study in humans and animal models, there remains a lack of consensus regarding how the action of electrical stimulation on neuronal and non-neuronal elements – e.g. neuropil, cell bodies, glial cells,...

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

Jessica C. Jimenez et al.
Nature Communications | July 13, 2020
Ventral hippocampal CA1 (vCA1) projections to the amygdala are necessary for contextual fear memory. Here we used in vivo Ca2+ imaging in mice to assess the temporal dynamics by which ensembles of vCA1 neurons mediate...

Midbrain modulation of conditioned learning

et al.
February 7, 2020
The firing activity of striatal cholinergic interneurons (CINs) is a neural correlate of conditioned learning. However, its circuitry is not entirely described. Here we report that midbrain GABA and Glutamate neurons...

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