nVoke Archives - Page 4 of 4

Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

Jan H. Lui et al.
Cell | December 17, 2020
Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience has historically analyzed the encoding properties of cortical neurons without considering cell...

Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake

Takashi Matsuda et al.
Nature Communications | November 10, 2020
The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water...

An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration

Paolo Botta et al.
Cell | October 7, 2020
Exploration of novel environments ensures survival and evolutionary fitness. It is expressed through exploratory bouts and arrests that change dynamically based on experience. Neural circuits mediating exploratory...

Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures

James K Trevathan et al.
Journal of Neural Engineering | September 11, 2020
After decades of study in humans and animal models, there remains a lack of consensus regarding how the action of electrical stimulation on neuronal and non-neuronal elements – e.g. neuropil, cell bodies, glial cells,...

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

Jessica C. Jimenez et al.
Nature Communications | July 13, 2020
Ventral hippocampal CA1 (vCA1) projections to the amygdala are necessary for contextual fear memory. Here we used in vivo Ca2+ imaging in mice to assess the temporal dynamics by which ensembles of vCA1 neurons mediate...

Midbrain modulation of conditioned learning

et al.
February 7, 2020
The firing activity of striatal cholinergic interneurons (CINs) is a neural correlate of conditioned learning. However, its circuitry is not entirely described. Here we report that midbrain GABA and Glutamate neurons...

Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

Diego Scheggia et al.
Nature Neuroscience | December 16, 2019
The prefrontal cortex (PFC) is implicated in processing of the affective state of others through non-verbal communication. This social cognitive function is thought to rely on an intact cortical neuronal excitatory and...

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Ying Sun et al.
eLife | August 14, 2019
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic...

VIP interneurons contribute to avoidance behavior by regulating information flow across hippocampal-prefrontal networks

Anthony T. Lee et al.
Neuron | April 30, 2019
Inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are known to disinhibit cortical neurons. However, it is unclear how disinhibition, occurring at the single-cell level, interacts with...

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli

Caitlin M. Vander Weele et al.
Nature | November 7, 2018
Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions1,2; however, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may...

Simultaneous Optogenetics and Cellular Resolution Calcium Imaging During Active Behavior Using a Miniaturized Microscope

Alice M. Stamatakis et al.
Frontiers in Neuroscience | July 24, 2018
The ability to precisely monitor and manipulate neural circuits is essential to understand the brain. Advancements over the last decade in optical techniques such as calcium imaging and optogenetics have empowered...

Fast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning

Scott F. Owen et al.
Cell | February 8, 2018
Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how...

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