nVoke Archives - Page 2 of 4

Unilateral Optogenetic Stimulation of Lhx6 Neurons in the Zona Incerta Increases REM sleep

Aurelio Vidal-Ortiz et al.
Sleep | August 21, 2023
To determine how a waking brain falls asleep researchers have monitored and manipulated activity of neurons and glia in various brain regions. While imaging GABA neurons in the zona incerta (ZI) we found a subgroup that...

Emergence of preparatory dynamics in VIP interneurons during motor learning

Sergio Arroyo et al.
Cell Reports | July 18, 2023
Study by Sergio Arroyo et al, investigates vasointestinal peptide (VIP) and somatostatin (SST) interneurons in the mouse secondary motor cortex during the acquisition of a cue-based reach-to-grasp task. VIP interneurons...

Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice

Kyohei Kin et al.
Nature Communications | May 23, 2023
In a recent study by Kyohei Kin et al., the impact of adolescent psychosocial stress on postpartum social behavior was examined. Using innovative techniques such as optogenetics and in vivo microendoscopic calcium...

Long-range inhibition synchronizes and updates prefrontal task activity

Kathleen K. A. Cho et al.
Nature | April 26, 2023
Changes in patterns of activity within the medial prefrontal cortex enable rodents,non-human primates and humans to update their behaviour to adapt to changes in the environment—for example, during cognitive tasks....

Control of contextual memory through interneuronal a5-GABAA receptors

Mengwen Zhu et al.
PNAS Nexus | April 11, 2023
γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABAARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal...

Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain

Yaling Liu et al.
Neuron | April 4, 2023
Liu et al. conducted a study on rats to investigate the neural mechanisms involved in pain processing and modulation. Using behavioral assays and calcium imaging techniques, they sought to understand how oxytocin...

Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

Young Hee Lee et al.
Nature Communications | March 17, 2023
For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known to regulate motivated behaviours, yet...

Disynaptic specificity of serial information flow for conditioned fear

LÉMA Massi et al.
Science Advances | January 20, 2023
Memory encoding and retrieval rely on specific interactions across multiple brain areas. Although connections between individual brain areas have been extensively studied, the anatomical and functional specificity of...

CaV3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum

Srdjan M. Joksimovic et al.
Neuropharmacology | December 29, 2022
The dorsal subiculum (dSub) is one of the key structures responsible for the formation of hippocampal memory traces but the contribution of individual ionic currents to its cognitive function is not well studied....

Tripartite extended amygdala–basal ganglia CRH circuit drives locomotor activation and avoidance behavior

Simon Chang et al.
Science Advances | November 16, 2022
An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin-releasing...

Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP

Mengwen Zhu et al.
Neuropharmacology | August 14, 2022
We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSPNMDA) or long-term potentiation (LTP) in...

A molecularly defined D1 medium spiny neuron subtype negatively regulates cocaine addiction

Zheng-dong Zhao et al.
Science Advances | August 12, 2022
The striatum plays a critical role in regulating addiction-related behaviors. The conventional dichotomy model suggests that striatal D1/D2 medium spiny neurons (MSNs) positively/negatively ...

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