nVoke Archives - Page 3 of 5

Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP

Mengwen Zhu et al.
Neuropharmacology | August 14, 2022
We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSPNMDA) or long-term potentiation (LTP) in...

A molecularly defined D1 medium spiny neuron subtype negatively regulates cocaine addiction

Zheng-dong Zhao et al.
Science Advances | August 12, 2022
The striatum plays a critical role in regulating addiction-related behaviors. The conventional dichotomy model suggests that striatal D1/D2 medium spiny neurons (MSNs) positively/negatively ...

Dopamine subsystems that track internal states

James C. R. Grove et al.
Nature | July 13, 2022
Food and water are rewarding in part because they satisfy our internal needs. Dopaminergic neurons in the ventral tegmental area (VTA) are activated by gustatory rewards, but how animals learn to associate these oral...

Pattern decorrelation in the mouse medial prefrontal cortex enables social preference and requires MeCP2

Pan Xu et al.
Nature Communications | July 6, 2022
Sociability is crucial for survival, whereas social avoidance is a feature of disorders such as Rett syndrome, which is caused by loss-of-function mutations in MECP2. To understand how a preference for social...

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

Ruchi Malik et al.
Cell | April 28, 2022
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways mediating top-down control remain poorly understood....

Encoding of environmental cues in central amygdala neurons during foraging

Marion Ponserre et al.
The Journal of Neuroscience | April 5, 2022
To successfully forage in an environment filled with rewards and threats, animals need to rely on familiar structures of their environment that signal food availability. The central amygdala (CeA) is known to mediate a...

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Joseph I. Terranova et al.
Neuron | February 8, 2022
The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior...

In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse

Aleisha M. Moore et al.
PNAS | February 8, 2022
A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) and is essential for reproduction. Recent evidence suggests...

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Débora Masini et al.
Nature Communications | January 26, 2022
The pedunculopontine nucleus (PPN) is a locomotor command area containing glutamatergic neurons that control locomotor initiation and maintenance. These motor actions are deficient in Parkinson’s disease (PD), where...

Identification of Sclareol As a Natural Neuroprotective Ca_v1.3-Antagonist Using Synthetic Parkinson-Mimetic Gene Circuits and Computer-Aided Drug Discovery

Hui Wang et al.
Advanced Science | January 18, 2022
Parkinson’s disease (PD) results from selective loss of substantia nigra dopaminergic (SNc DA) neurons, and is primarily caused by excessive activity-related Ca2+ oscillations. Although L-type voltage-gated...

Disrupted population coding in the prefrontal cortex underlies pain aversion

Anna Li et al.
Cell Reports | November 9, 2021
The prefrontal cortex (PFC) regulates a wide range of sensory experiences. Chronic pain is known to impair normal neural response, leading to enhanced aversion. However, it remains unknown how nociceptive responses in...

In vivo Calcium Imaging in Mouse Inferior Olive

Da Guo et al.
JOVE | June 10, 2021
Inferior olive (IO), a nucleus in the ventral medulla, is the only source of climbing fibers that form one of the two input pathways entering the cerebellum. IO has long been proposed to be crucial for motor control and...

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