nVista Archives - Page 3 of 17

Unilateral Optogenetic Stimulation of Lhx6 Neurons in the Zona Incerta Increases REM sleep

Aurelio Vidal-Ortiz et al.
Sleep | August 21, 2023
To determine how a waking brain falls asleep researchers have monitored and manipulated activity of neurons and glia in various brain regions. While imaging GABA neurons in the zona incerta (ZI) we found a subgroup that...

The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding

Christophe Varin et al.
Nature Communications | August 17, 2023
The basal ganglia are known to control actions and modulate movements. Neuronal activity in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral control. Previous evidence has led to...

A neural circuit for male sexual behavior and reward

Daniel W. Bayless et al.
Cell | August 11, 2023
A study conducted by Bayless et al. explores the neural basis of innate male sexual behavior and its rewarding nature. Using nVista for calcium imaging and fiber photometry, the researchers identified a developmentally...

A neural mechanism for discriminating social threat from social safety

Pegah Kassraian et al.
bioRxiv | July 27, 2023
The ability to distinguish a threatening from non-threatening conspecific based on past experience is critical for adaptive social behaviors. Although recent progress has been made in identifying the neural circuits...

Active experience, not time, determines within-day representational drift in dorsal CA1

Dorgham Khatib et al.
Neuron | June 13, 2023
Memories of past events can be recalled long after the event, indicating stability. But new experiences are also integrated into existing memories, indicating plasticity. In the hippocampus, spatial representations are...

Self-organization of songbird neural sequences during social isolation

Emily L Mackevicius et al.
eLife | May 30, 2023
Emily L. Mackevicius et al., using the Inscopix nVista tool, investigated whether the formation of sequences in the high vocal center (HVC) of songbirds depends on prior exposure to a tutor song. They found that even in...

Long-term optical imaging of the spinal cord in awake, behaving animals

Biafra Ahanonu et al.
bioRxiv | May 24, 2023
Advances in optical imaging approaches and fluorescent biosensors have enabled an understanding of the spatiotemporal and long-term neural dynamics in the brain of awake animals. However, methodological difficulties and...

Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia

Satvinder Kaur et al.
Research Square | May 5, 2023
Although CGRP neurons in the external lateral parabrachial nucleus (PBelCGRP neurons) are critical for cortical arousal in response to hypercapnia, activating them has little effect on respiration. However, deletion of...

Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice

Tadaaki Nishioka et al.
Nature Communications | April 21, 2023
Learned associations between environmental cues and the outcomes they predict (cue-outcome associations) play a major role in behavioral control, guiding not only which responses we should perform, but also which we...

Identification of an essential spinoparabrachial pathway for mechanical itch

Xiangyu Ren et al.
Neuron | April 5, 2023
The study identified a specific population of neurons that transmit mechanical itch from the spinal cord to the parabrachial nucleus (PBN) in the brain, and separate populations of neurons in the PBN relay mechanical...

Experience-dependent changes in affective valence of taste in male mice

Shun Hamada et al.
Molecular Brain | March 11, 2023
The study conducted by Hamada et al. utilized nVista in vivo calcium imaging to examine the responses of central amygdala (CeA) neurons to sweet, umami, and bitter tastants. This innovative approach provided insights...

Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex

Jennifer Isaac et al.
bioRxiv | March 10, 2023
The reinforcing nature of social interactions is necessary for the maintenance of appropriate social behavior. However, the neural substrates underlying social reward and whether these are shared with competing...

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